Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations
BACKGROUND IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel diseases. Here we investigated whether polymorphisms in the IRF5 gene would be associated with yet another disease with features of autoimmu...
متن کاملCrohn's associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis.
Crohn's associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis Autoimmune diseases, such as multiple sclerosis and Crohn's disease, are believed to result from the effects of environmental agents acting on genetically susceptible individuals. Evidence from segregation analysis and systematic whole genome linkage studies indicates that the nature of th...
متن کاملPolymorphisms within Exon 9, But Not Intron 8, of the Vitamin D Receptor Gene Are Associated with Asthma
Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron ...
متن کاملCommon genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis.
Matrix metalloproteinase 9 (MMP9) is involved in multiple sclerosis (MS) aetiology. Previously, we identified differential gene expression of plasminogen activation cascade genes in MS patients. Based on our gene expression results, we wanted to identify whether polymorphisms in the genes associated with the plasminogen pathway could predict MS risk. We genotyped 1153 trio families, 727 MS case...
متن کاملKIBRA gene variants are associated with synchronization within the default-mode and executive control networks
Genetic variation at the KIBRA rs17070145 polymorphism has been linked to episodic memory, executive function, and Alzheimer's disease (AD), which are related to the structural and functional integrity of the default-mode network (DMN) and executive control network (ECN). We hypothesize that the KIBRA polymorphism could modulate the structure and function of the DMN and ECN in healthy young sub...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Genetics
سال: 2010
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.584